If something can go wrong, it will.

neurosciencestuff:

Glucose ‘control switch’ in the brain key to both types of diabetes
Researchers at Yale School of Medicine have pinpointed a mechanism in part of the brain that is key to sensing glucose levels in the blood, linking it to both type 1 and type 2 diabetes. The findings are published in the July 28 issue of Proceedings of the National Academies of Sciences.
“We’ve discovered that the prolyl endopeptidase enzyme — located in a part of the hypothalamus known as the ventromedial nucleus — sets a series of steps in motion that control glucose levels in the blood,” said lead author Sabrina Diano, professor in the Departments of Obstetrics, Gynecology & Reproductive Sciences, Comparative Medicine, and Neurobiology at Yale School of Medicine. “Our findings could eventually lead to new treatments for diabetes.”
The ventromedial nucleus contains cells that are glucose sensors. To understand the role of prolyl endopeptidase in this part of the brain, the team used mice that were genetically engineered with low levels of this enzyme. They found that in absence of this enzyme, mice had high levels of glucose in the blood and became diabetic.
Diano and her team discovered that this enzyme is important because it makes the neurons in this part of the brain sensitive to glucose. The neurons sense the increase in glucose levels and then tell the pancreas to release insulin, which is the hormone that maintains a steady level of glucose in the blood, preventing diabetes.
“Because of the low levels of endopeptidase, the neurons were no longer sensitive to increased glucose levels and could not control the release of insulin from the pancreas, and the mice developed diabetes.” said Diano, who is also a member of the Yale Program in Integrative Cell Signaling and Neurobiology of Metabolism.
Diano said the next step in this research is to identify the targets of this enzyme by understanding how the enzyme makes the neurons sense changes in glucose levels. “If we succeed in doing this, we could be able to regulate the secretion of insulin, and be able to prevent and treat type 2 diabetes,” she said.

neurosciencestuff:

Glucose ‘control switch’ in the brain key to both types of diabetes

Researchers at Yale School of Medicine have pinpointed a mechanism in part of the brain that is key to sensing glucose levels in the blood, linking it to both type 1 and type 2 diabetes. The findings are published in the July 28 issue of Proceedings of the National Academies of Sciences.

“We’ve discovered that the prolyl endopeptidase enzyme — located in a part of the hypothalamus known as the ventromedial nucleus — sets a series of steps in motion that control glucose levels in the blood,” said lead author Sabrina Diano, professor in the Departments of Obstetrics, Gynecology & Reproductive Sciences, Comparative Medicine, and Neurobiology at Yale School of Medicine. “Our findings could eventually lead to new treatments for diabetes.”

The ventromedial nucleus contains cells that are glucose sensors. To understand the role of prolyl endopeptidase in this part of the brain, the team used mice that were genetically engineered with low levels of this enzyme. They found that in absence of this enzyme, mice had high levels of glucose in the blood and became diabetic.

Diano and her team discovered that this enzyme is important because it makes the neurons in this part of the brain sensitive to glucose. The neurons sense the increase in glucose levels and then tell the pancreas to release insulin, which is the hormone that maintains a steady level of glucose in the blood, preventing diabetes.

“Because of the low levels of endopeptidase, the neurons were no longer sensitive to increased glucose levels and could not control the release of insulin from the pancreas, and the mice developed diabetes.” said Diano, who is also a member of the Yale Program in Integrative Cell Signaling and Neurobiology of Metabolism.

Diano said the next step in this research is to identify the targets of this enzyme by understanding how the enzyme makes the neurons sense changes in glucose levels. “If we succeed in doing this, we could be able to regulate the secretion of insulin, and be able to prevent and treat type 2 diabetes,” she said.

(via thenewenlightenmentage)

thefandomtolllbooth:

antoinetriplett:

jolivet:

spaceman-v-spiff:

nescientes:

novacayyn:

carry-on-my-otp:

If Stuntmen from the old movies don’t have your full respect then I just don’t know what to say to you

l tried really hard not to reblog this

Yeah, it is indeed really hard not to reblog a fucking thing.

Can we all agree that the man in the first gif is the manliest man in the world?

Are we just going to all silently acknowledge that the last guy is clearly dead and that we just saw him die. 

HOLD UP FOR A SECOND

ALL OF THESE GIFS ARE ONE MAN

THE SINGULAR BUSTER KEATON

WHILE FILMING THE GENERAL

HE SNAPPED HIS NECK ON THE RAILROAD TIES AND WENT HOME AND ICED HIS BODY

AND CAME BACK FOR WORK THE NEXT DAY

HE ONCE GOT HIS HIP RIPPED OUT OF ITS SOCKET BY A MALFUNCTIONING ELEVATOR AND WAS DISAPPOINTED WITH HIMSELF FOR BEING INJURED

HE ONCE HAD TO FALL 100 FEET DOWN A WATERFALL INTO A NET

A STUNTMAN TESTED IT AND BROKE BOTH LEGS AND DISLOCATED HIS SHOULDER

BUSTER DID THE STUNT ANYWAY AND LANDED WITHOUT A SCRATCH

IN ‘THE HIGH DIVE’

BUSTER DID A TRICK DIVE THROUGH A CARDBOARD DECK THAT WAS CAMOUFLAGED TO LOOK LIKE THE REAL DECK

ONLY HE COULDN’T TELL FROM 100 FEET UP WHERE THE CARDBOARD STOPPED AND THE REAL DECK STARTED AND THERE WAS ONLY LIKE A THREE FOOT MARGIN FOR ERROR

AND WHEN HE HESITATED A SUDDEN BREEZE LITERALLY KNOCKED HIM OFF THE DIVING BOARD AND HE HAD TO JUMP ANYWAY

AND HE MISSED THE REAL DECK BY LESS THAN A FOOT BUT HE MADE IT

IN THE SECOND GIF HE’S RECREATING SOMETHING THAT THE ACTUAL GENERAL PURSUERS HAD TO DO IN THE CIVIL WAR

IF HE MISSES THAT TIE

THE TRAIN WILL BE DERAILED AND HE WILL DIE IN THE EXPLOSION

IN THE THIRD GIF AN ENTIRE HOUSE IS FALLING HE HAS ONE TAKE AND IF HE HAS NOT DONE THE CALCULATIONS CORRECTLY HE WILL BE CRUSHED

HE HAS AN INCH-WIDE MARGIN ON EACH SIDE

AND THE HOUSE LITERALLY BRUSHES HIS LEFT SHOULDER ON THE WAY DOWN

YOU CAN SEE HIS LEFT ARM JUMP BECAUSE HE’S FLINCHING FROM THE PAIN

THAT LAST GIF

HE WAS SUPPOSED TO MAKE THAT JUMP

HE WAS NOT SUPPOSED TO FALL AND THEY HADNT PLANNED FOR IT

BUT HE SURVIVED

BUSTER KEATON SURVIVED 100% OF THINGS THAT WOULD HAVE KILLED LESSER MEN INCLUDING WWI, TORNADOS, HOUSEFIRES, ALCOHOLISM, BROKEN NETS, CRUSHING DEPRESSION, THE DEPRESSION ITSELF, THE MCCARTHY WITCHHUNTS, THE END OF SILENT CINEMA, AND ABOUT 900 MORE OF THE STUNTS YOU SEE ABOVE

BUSTER LIVED TO BE 70 YEARS OLD

FATHERED LIKE FOUR KIDS AND EIGHT GRANDKIDS

HE CAME OUT THE OTHER SIDE OF ALL THAT

THINKING THAT LIFE WAS GOOD AND PEOPLE WERE WONDERFUL

BUSTER KEATON IS NOT JUST A STUNTMAN

HE IS A GODDAMN SAINT

BUSTER KEATON’S PARENTS WERE PART OF A TRAVELING SHOW.

THEY WERE ACROBATS.

THEY TOOK BABY BUSTER UP HIGH IN THE AIR WITH THEM.

THEY DROPPED HIM.

LUCKILY SOMEONE WHO WAS STANDING UNDER THEM CAUGHT BABY BUSTER.

THAT MAN WAS HARRY HOUDINI. 

HARRY HOUDINI SAVED BUSTER KEATON’S LIFE.

if you don’t think that’s the coolest shit you can get right out.

(via pencil-rebagels)